Cell Line Development Process

It s in our dna. We do this for both gs system cell lines and cell lines brought to us by our customers. In the case of monoclonal antibody production the process of developing stable cell lines starts with transfecting host cells with recombinant plasmid dna encoding the.

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Cell line development workflow in order to generate high yields of recombinant protein products stable cell lines such as cho or hek 293 are typical vehicles of choice.

Cell line development process.

Cell line development our strength is to generate high performance production cell lines under a target product profile by our proprietary cho expression technologies. Cell line development and assurance of monoclonality are critical steps in the process of generating biopharmaceutical molecules such as monoclonal antibodies. All gibco cho cell line development products are cgmp compliant with no need to source components or develop vectors allowing you to focus on moving your workflow from cell line to process development. Our services in stable cell line development and recombinant protein manufacturing cover the value chain from dna construction and transfection to cho and hek process development to large scale protein production.

Get the best start for your development processes. A cell line can be established following the isolation of a single viable cell robustly expressing the protein of interest. With a proven track record in cell culture we offer a complete range of development services to establish a cell line and process that meet your needs and are suitable for manufacturing product for clinical or commercial supply. Our cgmp compliant facility enables the generation of master cell banks and master working banks mcb mwb.

We are implementing state of the art single cell printer and high resolution imager to ensure monoclonality and to reduce the time of single cell cloning. New for 2020 this year s cell line development engineering us meeting is co located as part of bioprocess international us west providing you with a unique opportunity to connect and learn from 1000 global scientists working further down the bioprocessing spectrum across upstream downstream analytics and commercial manufacturing.

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